Harnessing the untapped potential of nucleotide‐binding oligomerization domain ligands for cancer immunotherapy
نویسندگان
چکیده
منابع مشابه
Harnessing the antitumor potential of macrophages for cancer immunotherapy
Macrophages constitute a dominant fraction of the population of immune cells that infiltrate developing tumors. Recruited by tumor-derived signals, tumor-infiltrating macrophages are key orchestrators of a microenvironment that supports tumor progression. However, the phenotype of macrophages is pliable and, if instructed properly, macrophages can mediate robust antitumor functions through thei...
متن کاملHarnessing Africa's untapped solar energy potential for health.
Dr Sam Wamani’s sister-in-law bled to death in his arms, a victim of obstetric complications. “It happened 10 years ago,” says the 33-year-old resident of Leba, in western Uganda. “My brother came to my door at 1 am. I had just graduated from medical school in Kampala, and he thought I could help. I said we had to get her to the health unit.” She could not walk, so they wheeled her on a bicycle...
متن کاملHarnessing B cells for cancer immunotherapy
B cells are one of the two adaptive arms partnering with T cells in immune defense system against infections by virus, bacteria, fungi and parasites [1]. Originated from hematopoietic stem cells in bone marrow, B cells contain multiple subsets including antibody-secreting cells, antigen-presenting cells (APC), innate B effector cells and regulatory B cells [2]. As a heterogeneous population, B ...
متن کاملHarnessing the Microbiome to Enhance Cancer Immunotherapy
The microbiota plays a key role in regulating the innate and adaptive immune system. Herein, we review the immunological aspects of the microbiota in tumor immunity in mice and man, with a focus on toll-like receptor (TLR) agonists, vaccines, checkpoint modulators, chemotherapy, and adoptive T cell transfer (ACT) therapies. We propose innovative treatments that may safely harness the microbiota...
متن کاملThe interplay of immunotherapy and chemotherapy: harnessing potential synergies.
Although cancer chemotherapy has historically been considered immune suppressive, it is now accepted that certain chemotherapies can augment tumor immunity. The recent success of immune checkpoint inhibitors has renewed interest in immunotherapies, and in combining them with chemotherapy to achieve additive or synergistic clinical activity. Two major ways that chemotherapy promotes tumor immuni...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Medicinal Research Reviews
سال: 2018
ISSN: 0198-6325,1098-1128
DOI: 10.1002/med.21557